Perkins M.J.Rosario D.J.Wickes B.L.Krajaejun T.Sherwood J.E.Mody R.M.Mahidol University2023-06-182023-06-182022-07-01Travel Medicine and Infectious Disease Vol.48 (2022)14778939https://repository.li.mahidol.ac.th/handle/20.500.14594/85770Background: Human pythiosis, caused primarily by the aquatic oomycete, Pythium insidiosum, is an emerging but uncommon infection in North America. The infection is frequently life-threatening and is often initially unrecognized due to its rarity and similar presentation to certain fungal infections. Methods: We report a case of skin and soft tissue pythiosis in a patient without significant underlying comorbidities acquired in a New Mexico hot spring and review its successful treatment. We also review all reported pythiosis cases in North America. Results: Eleven confirmed cases of human pythiosis acquired in North America were identified. The majority of cases occurred in children (64%), ten of eleven cases were acquired in the southern U.S., Mexico, Central America or the Caribbean and four of the eleven individuals succumbed to the infection. Conclusions: With recognition and aggressive surgical and medical treatment good clinical outcomes can be achieved when treating human pythiosis.MedicineArticleSCOPUS10.1016/j.tmaid.2022.1023492-s2.0-851303253581873044235490949