Pattama PittayakhajonwutMan TheerasilpPalangpon KongsaereeAmporn RungrodMorakot TanticharoenYodhathai ThebtaranonthThailand National Center for Genetic Engineering and BiotechnologyMahidol University2018-07-242018-07-242002-11-01Planta Medica. Vol.68, No.11 (2002), 1017-1019003209432-s2.0-18744369890https://repository.li.mahidol.ac.th/handle/20.500.14594/19967A novel secondary metabolite, pughiinin A, together with pycnidione, mevalonolactone, and 7-hydroxy-2-methylchromanone, was isolated from the seed fungus Kionochaeta pughii BCC 3878. The chemical structure was established by spectroscopic methods and by single crystal X-ray crystallography. Pughiinin A and pycnidione exhibited in vitro antiplasmodial activity against Plasmodium falciparum (K1 strain). Pycnidione also showed anti-cancer activity against KB and BC cell lines with the IC50 values of 2.0 and 1.6 μg/mL, respectively.Mahidol UniversityAgricultural and Biological SciencesChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1055/s-2002-35653