Sutthasupha P.Promsan S.Thongnak L.Pengrattanachot N.Phengpol N.Jaruan O.Jaikumkao K.Muanprasat C.Pichyangkura R.Chatsudthipong V.Lungkaphin A.Mahidol University2023-06-182023-06-182022-07-15Carbohydrate Polymers Vol.288 (2022)01448617https://repository.li.mahidol.ac.th/handle/20.500.14594/85078Consumption of a high-fat diet (HFD) not only increases the risk of metabolic syndrome but also initiates kidney injury. Lipid accumulation-induced systemic low-grade inflammation is an upstream mechanism of kidney injury associated with prediabetes. Chitosan oligosaccharide (COS) provides potent anti-obesity effects through several mechanisms including fecal lipid excretion. In this study, we investigated the effects of COS on the prevention of obesity-related complications and its ability to confer renoprotection in a prediabetic model. Rats fed on a HFD developed obesity, glucose intolerance and kidney dysfunction. COS intervention successfully ameliorated these conditions (p < 0.05) by attenuating intestinal lipid absorption and the renal inflammation-autophagy-apoptosis axis. A novel anti-inflammatory effect of COS had been demonstrated by the strengthening of intestinal barrier integrity via calcium-sensing receptor (p < 0.05). The use of COS as a supplement may be useful in reducing prediabetic complications especially renal injury and the risk of type 2 diabetes.Materials ScienceArticleSCOPUS10.1016/j.carbpol.2022.1194052-s2.0-8512699427735450657