Nalat SompagdeeChenchit ChayachindaFrancois W.D. VenterKanokwaroon WatananirunUniversity of WitwatersrandFaculty of Medicine, Siriraj Hospital, Mahidol University2019-08-282019-08-282018-01-01Siriraj Medical Journal. Vol.70, No.1 (2018), 87-90222880822-s2.0-85051603735https://repository.li.mahidol.ac.th/handle/20.500.14594/47144© 2018, Faculty of Medicine Siriraj Hospital, Mahidol University. Objective: To present outcomes of expectant management (EM) in HIV-infected pregnancy with preterm premature rupture of membranes (PPROM) at less than 34-week gestation. Case presentation: During January 2008-December 2015, there were 513 HIV-infected pregnant women giving birth at Siriraj Hospital, Thailand. Ten of them presented with PPROM at GA <34 weeks and six women received EM. The deliveries took place at GA 28 2/7 -33 5/7 weeks. The longest interval of ROM was 15 days and the highest on-admission viral load was 633,000 copies/mL. Three of them had antepartum highly active antiretroviral therapy (HAART) for at least four weeks prior to the delivery. Mode of delivery included 3 vaginal deliveries and 3 caesarean sections. All infants' HIV molecular tests were negative at birth. The longest follow-up interval was 12 months and HIV vertical transmission remained negative. Conclusion: Expectant management in HIV-infected women with PPROM at GA <34 weeks may be sensible because complications of prematurity outweigh the risk of vertical HIV transmission.Mahidol UniversityMedicineArticleSCOPUS10.14456/smj.2018.15