Witaya ThamavitMaya NgamyingVijitr BoonpucknavigSomnate BoonpucknavigMalcolm A. MooreMahidol UniversityUniversity of New South Wales (UNSW) Australia2018-06-142018-06-141987-09-01Carcinogenesis. Vol.8, No.9 (1987), 1351-1353014333342-s2.0-0023228260https://repository.li.mahidol.ac.th/handle/20.500.14594/15311The influence of Opisthorchis viverrini liver fluke infection on development of diethylnitrosamine (DEN)-induced hepatocellular nodules was investigated in Syrian golden hamsters. Infection with 60 metacercariae, 4 weeks prior to administration of DEN for 12 weeks in the drinking water at dose levels of 10, 20 and 40 p.p.m., resulted in a significantly increased yield of nodular lesions as compared with the group receiving carcinogen treatment alone. The results indicate an importance for parasite-associated liver injury and compensatory regeneration in hepatocarcinogenesis and suggest a possible role for Opisthorchis infestation in the generation of hepatocellular tumours in man. © 1987 IRL Press Limited.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1093/carcin/8.9.1351