Saovaree TanpantreePakorn OpaprakasitDuangporn PolpanichSrung SmanmooPramuan TangboriboonratMahidol UniversitySirindhorn International Institute of Technology, Thammasat UniversityThailand National Science and Technology Development AgencyThailand National Center for Genetic Engineering and Biotechnology2018-09-242018-09-242010-08-01Journal of Biomedical Nanotechnology. Vol.6, No.4 (2010), 385-39015507041155070332-s2.0-79953012455https://repository.li.mahidol.ac.th/handle/20.500.14594/28894Poly(methyl acrylate) (PMA) of various weight average molecular weights (M̄w) were synthesized via the iniferter route and applied for the encapsulation of disinfectant agent (chlorhexidine digluconate; CHD) by using the controlled precipitation technique. The encapsulation efficiency of CHD-PMA nanocapsules suspended in cyclohexane increased from 70 to 100% when the M̄w of PMA increased from 40 K to 550 K. After redispersing the capsules into 0.5% w/v of sodium dodecyl sulphate aqueous solution, the maximum content of CHD in the nanocapsules remained >90%. Transmission electron micrographs showed the spherical nanocapsule with continuous intact shell. Copyright © 2010 American Scientific Publishers. All rights reserved.Mahidol UniversityChemical EngineeringEngineeringMaterials ScienceMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1166/jbn.2010.1134