Florian GrundmannMarcel KaiserMatthias SchiellAndreas BatzerMichael KurzAunchalee ThanwisaiNarisara ChantratitaHelge B. BodeGoethe-Universitat Frankfurt am MainSwiss Tropical and Public Health Institute (Swiss TPH)Sanofi RandDNaresuan UniversityMahidol University2018-11-092018-11-092014-04-25Journal of Natural Products. Vol.77, No.4 (2014), 779-78315206025016338642-s2.0-84899573046https://repository.li.mahidol.ac.th/handle/20.500.14594/33269A new class of four depsipentapeptides called chaiyaphumines A-D (1-4) was isolated from Xenorhabdus sp. PB61.4. Their structures were elucidated by detailed 1D and 2D NMR experiments and by a Marfeys analysis following flash hydrolysis of the peptide. Verification of the structure was achieved by three-dimensional modeling using NOE-derived distance constraints, molecular dynamics, and energy minimization. Chaiyaphumine A (1) showed good activity against Plasmodium falciparum (IC50 of 0.61 μM), the causative agent of malaria, and was active against other protozoal tropical disease causing agents. © 2014 The American Chemical Society and American Society of Pharmacognosy.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1021/np4007525