Sirintip SricharoenchaiStephen J. KerrStephen J. KerrSivaporn GatechompolRawiwan HansudewechakulHanh Le Dung DangDan Ngoc Hanh TranNipat TeeratakulpisarnAmphan ChalermchockcharoenkitJullapong AchalapongSirinya TeeraananchaiThida SingtorojNittaya PhanuphakAnnette H. SohnKulkanya ChokephaibulkitThai Red Cross AgencyChulalongkorn UniversityKasetsart UniversityThe HIV Netherlands Australia Thailand Research CollaborationFaculty of Medicine, Siriraj Hospital, Mahidol UniversityChildren's Hospital 1Foundation for AIDS ResearchChiangrai Prachanukroh HospitalHung Vuong Hospital2020-08-252020-08-252020-01-01Pediatric Infectious Disease Journal. (2020), 615-61915320987089136682-s2.0-85086345971https://repository.li.mahidol.ac.th/handle/20.500.14594/58331© 2020 Wolters Kluwer Health, Inc. All rights reserved. Background: We studied the prevalence of 7, high-risk human papillomavirus (HPV) types in the nonavalent vaccine (HRVT-7: HPV 16, 18, 31, 33, 45, 52, 58) among vaccine-naïve, sexually active Asian female adolescents with and without perinatally acquired HIV infection (PHIV). Methods: PHIV female adolescents 12-24 years of age and HIV-uninfected controls matched by age and number of lifetime sex partners were enrolled in a 3-year observational cohort study in Thailand and Vietnam. Samples from the oral cavity, anus, cervix and vagina were collected for HRVT-7 HPV genotyping, and serum collected for HPV 16 and 18 antibody testing. Baseline data were analyzed using multivariable logistic regression. Results: We included 93 PHIV (median CD4 593 cells/mm3, 62% with HIV RNA suppression) and 99 HIV-uninfected adolescents (median lifetime sex partners 2). The overall prevalence of HRVT-7 infection was 53% in PHIV and 49% in HIV-uninfected adolescents (P = 0.66). Cervical HRVT-7 DNA was detected more frequently in PHIV than HIV-uninfected adolescents (37% vs. 23%, P = 0.04). Overall, more lifetime partners [≥3 vs. 1; odds ratio (OR) 2.99 (1.38-6.51), P = 0.02] and having other sexually transmitted infections [OR 3.30 (1.51-7.21), P = 0.003] increased the risk of HRVT-7 infection and/or positive HPV 16/18 antibodies; while detectable HIV RNA [OR 2.78 (1.05-7.36), P = 0.04] increased the risk among PHIV adolescents. Conclusions: Half of sexually active Asian female adolescents, regardless of HIV infection, had already acquired HRVT-7 infection. This underscores the need for earlier access to HPV vaccine in the region.Mahidol UniversityMedicineArticleSCOPUS10.1097/INF.0000000000002659