Jiraphong SuksiriworapongKittisak SriphaKreuter, JorgVaraporn Buraphacheep Junyaprasertจิรพงศ์ สุขสิริวรพงศ์กิตติศักดิ์ ศรีภาวราภรณ์ บูรพาชีพ จรรยาประเสริฐMahidol University. Faculty of Pharmacy. Department of PharmacyMahidol University. Faculty of Pharmacy. Department of Pharmaceutical Chemistry2012-04-042021-03-242012-04-042021-03-242012International Journal of Pharmaceutics. Vol.423, No.2 (2012), 562-70.0378-5173https://repository.li.mahidol.ac.th/handle/20.500.14594/61406Nicotinic acid was grafted on (poly(e-caprolactone))2-poly(ethylene glycol) copolymers that were used for the preparation of nanoparticles with the objectives to monitor particle size and to optimize the drug loading capacity as well as the release profile of the particles. Increasing amounts of grafting nicotinic acid increased the particle size as a result of an enhanced hydrophobicity of the copolymer. Ibuprofen and indomethacin with two different molecular characteristics were selected as model drugs to be bound to the nanoparticles. The presence of grafting nicotinic acid enhanced the loading capacity for both drugs compared to the nanoparticles without nicotinic acid. However, no correlation between amount of grafting nicotinic acid and loading capacity was observed. The release characteristic of both drugs was fitted to the Higuchi model indicating Fickian diffusion. The release characteristic of indomethacin mainly depended on the crystalline property of the copolymer whereas that of ibuprofen was additionally influenced by the hydrogen bonding between drug and grafted copolymer.engMahidol UniversityIbuprofenIndomethacinNanoparticleNicotinic acidPoly(e-caprolactone)Poly(ethylene glycol)Drug carrierDrug delivery systemHydrogen bondingCopolymerResearch Article2011-10-13Elsevier (available from ScienceDirect)10.1016/j.ijpharm.2011.00.033