Khie Chen LieChuen Yen LauNguyen Van Vinh ChauT. Eoin WestDirek LimmathurotsakulPratiwi SudarmonoAbu Tholib AmanMansyur ArifArmaji Kamaludi SyarifHerman KosasihMuhammad KaryanaTawee ChotpitayasunondhWarunee Punpanich VandepitteAdiratha BoonyasiriKeswadee LapphraKulkanya ChokephaibulkitPinyo RattanaumpawanVisanu ThamlikitkulAchara LaongnualpanichPrapit TeparrakkulPramot SrisamangPhan Huu PhucLe Thanh HaiNguyen Van KinhBui Duc PhuNguyen Thanh HungTang Chi ThuongHa Manh TuanLam Minh YenNguyen Van Vinh ChauJanjira ThaipadungpanitStuart BlacksellNicholas DayClaire LingGuy ThwaitesHeiman WertheimLe Van TanMotiur RahmanH. Rogier van DoornSappasitthiprasong HospitalBadan Penelitian Dan Pengembangan Kesehatan, Kementerian Kesehatan Republik IndonesiaUniversity of Indonesia, RSUPN Dr. Cipto MangunkusumoUCLNational Institute of Allergy and Infectious DiseasesUniversity of Washington, SeattleMahidol UniversityFaculty of Medicine, Siriraj Hospital, Mahidol UniversityQueen Sirikit National Institute of Child HealthNuffield Department of Clinical MedicineOxford University Clinical Research UnitHue Central HospitalNational Hospital of PeadiatricsWahidin Soedirohusodo HospitalShoklo Malaria Research UnitChildren's Hospital 2Children's Hospital 1Sardjito HospitalNational Hospital of Tropical DiseasesChiangrai Prachanukroh HospitalOxford University Clinical Research Unit2019-08-282019-08-282018-02-14Journal of Intensive Care. Vol.6, No.1 (2018)205204922-s2.0-85042110251https://repository.li.mahidol.ac.th/handle/20.500.14594/46945© 2018 The Author(s). Background: Sepsis is a global threat but insufficiently studied in Southeast Asia. The objective was to evaluate management, outcomes, adherence to sepsis bundles, and mortality prediction of maximum Sequential Organ Failure Assessment (SOFA) scores in patients with community-acquired sepsis in Southeast Asia. Methods: We prospectively recruited hospitalized adults within 24 h of admission with community-acquired infection at nine public hospitals in Indonesia (n=3), Thailand (n=3), and Vietnam (n=3). In patients with organ dysfunction (total SOFA score ≥2), we analyzed sepsis management and outcomes and evaluated mortality prediction of the SOFA scores. Organ failure was defined as the maximum SOFA score ≥3 for an individual organ system. Results: From December 2013 to December 2015, 454 adult patients presenting with community-acquired sepsis due to diverse etiologies were enrolled. Compliance with sepsis bundles within 24 h of admission was low: broad-spectrum antibiotics in 76% (344/454), ≥1500 mL fluid in 50% of patients with hypotension or lactate ≥4 mmol/L (115/231), and adrenergic agents in 71% of patients with hypotension (135/191). Three hundred and fifty-five patients (78%) were managed outside of ICUs. Ninety-nine patients (22%) died. Total SOFA score on admission of those who subsequently died was significantly higher than that of those who survived (6.7 vs. 4.6, p<0.001). The number of organ failures showed a significant correlation with 28-day mortality, which ranged from 7% in patients without any organ failure to 47% in those with failure of at least four organs (p<0.001). The area under the receiver operating characteristic curve of the total SOFA score for discrimination of mortality was 0.68 (95% CI 0.62-0.74). Conclusions: Community-acquired sepsis in Southeast Asia due to a variety of pathogens is usually managed outside the ICU and with poor compliance to sepsis bundles. In this population, calculation of SOFA scores is feasible and SOFA scores are associated with mortality.Mahidol UniversityMedicineArticleSCOPUS10.1186/s40560-018-0279-7