Chao T.F.Lau C.P.Choi E.K.Ching C.K.Chan N.Y.Hung C.L.Joung B.Krittayaphong R.Tse H.F.Lip G.Y.H.Mahidol University2025-12-152025-12-152025-12-01Lancet Regional Health Western Pacific Vol.65 (2025)https://repository.li.mahidol.ac.th/handle/123456789/113524Device-detected atrial fibrillation (DDAF), including atrial high-rate episodes recorded at a cardiovascular implantable electronic device and subclinical atrial fibrillation detected by insertable cardiac monitor and smart wearables, poses an increasing challenge in stroke prevention. Although oral anticoagulants (OACs) are effective in clinical AF, their benefit-risk balance in DDAF remains uncertain. In response, the Asia Pacific Heart Rhythm Society (APHRS) proposes the 4S-DDAF approach (Strip documentation and longest AF duration, Symptoms, Stroke [ischemic] history, and Score) to guide anticoagulation decisions. This approach integrates electrogram review, symptom assessment, history of ischemic stroke or transient ischemic attack (TIA), and CHA<inf>2</inf>DS<inf>2</inf>-VASc scoring, emphasizing individualized care. OACs are recommended for patients with AF episodes ≥24 h, prior stroke/TIA, CHA<inf>2</inf>DS<inf>2</inf>-VASc score ≥4, or vascular disease. In patients not meeting these thresholds, close monitoring and risk factor management are advised. The 4S-DDAF approach provides a practical and evidence-informed strategy for clinical decision-making in the management of DDAF.MedicineReviewSCOPUS10.1016/j.lanwpc.2025.1017702-s2.0-10502419949526666065