Doonyapat Sa-nguanraksaPornchai O-charoenratMahidol University2018-06-112018-06-112012-01-01International Journal of Molecular Sciences. Vol.13, No.11 (2012), 14845-1486414220067166165962-s2.0-84870704754https://repository.li.mahidol.ac.th/handle/20.500.14594/13852Breast cancer is the most common cancer in females and the leading cause of cancer death in women worldwide. Angiogenesis, the formation of new blood vessels, plays an important role in the development and progression of breast cancer. Vascular endothelial growth factor A (VEGFA), the key modulator of angiogenesis, is highly expressed in cancer tissue and correlates with its more aggressive features. Polymorphisms of VEGFA alter the levels of expression and subsequently influence the susceptibility and aggressiveness of breast cancer. Assessment of VEGFA polymorphisms may be used for the identification of patients suitable for anti-VEGFA therapy. © 2012 by the authors; licensee MDPI, Basel, Switzerland.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemical EngineeringChemistryComputer ScienceMedicineReviewSCOPUS10.3390/ijms131114845