Tuchinda, S.Beale, D.Lehmann, H.Mahidol University. Faculty of Medical Sciences, Siriraj Hospital. Department of PediatricsUniversity Department of Biochemistry, Cambridge. Medical Research Council, Abnormal Haemoglobin Research Unit2020-02-172020-02-172020-02-171967Humangenetik. Vol.3, (1967), 312–318https://repository.li.mahidol.ac.th/handle/20.500.14594/52426The blood of two infants with Haemoglobin E trait and a form of α-thalassaemia (Haemoglobin H Disease) was examined and it was confirmed that the proportion of Haemoglobin A:E was higher than in uncomplicated Haemoglobin E trait. Haemoglobin H (β 4A) was added to the haemoglobin solution from a Haemoglobin E trait carrier. This mixture was dissociated into its α2, β 2A and β 2E subunits, and these were then recombined. The proportion of A:E had risen to that found in vivo in Haemoglobin E trait carriers with Haemoglobin H Disease. It is suggested that competition between βA and βE for α-chains may be an example of the mechanism by which α-thalassaemia ‘interacts’ with β-chain abnormal haemoglobins.engMahidol UniversityHaemoglobin E synthesisHaemoglobin E traitHaemoglobin H DiseaseSuppressionResearch ArticleSpringer Nature