Demetris PillasClive J. HoggartDavid M. EvansPaul F. O'ReillyKirsi SipiläRaija LähdesmäkiIona Y. MillwoodMarika KaakinenGopalakrishnan NetuveliDavid BlanePimphen CharoenUlla SovioAnneli PoutaNelson FreimerAnna Liisa HartikainenJaana LaitinenSarianna VaaraBeate GlaserPeter CrawfordNicholas J. TimpsonSusan M. RingGuohong DengWeihua ZhangMark I. McCarthyPanos DeloukasLeena PeltonenPaul ElliottLachlan J.M. CoinGeorge Davey SmithMarjo Riitta JarvelinImperial College LondonInternational Centre for LifeUCL Institute of Child HealthUniversity of BristolOulun YliopistoOulu University HospitalUniversity of OxfordMahidol UniversityNational Institutes of Health, BethesdaJane &amp; Terry Semel Institute for Neuroscience &amp; Human BehaviorUniversity of California, Los AngelesTyoterveyslaitosWellcome Trust Centre for Human GeneticsWellcome Trust Sanger InstituteInstitute for Molecular Medicine Finland (FIMM)Helsingin YliopistoNational Institute for Health and WelfareMedical Research Council2018-09-242018-09-242010-02-01PLoS Genetics. Vol.6, No.2 (2010)15537404155373902-s2.0-77649210349https://repository.li.mahidol.ac.th/handle/20.500.14594/28540Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P<5×10-8, and 5 with suggestive association (P<5×10-6). The loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3). Genes at four of the identified loci are implicated in the development of cancer. A variant within the HOXB gene cluster associated with occlusion defects requiring orthodontic treatment by age 31 years. © 2010 Pillas et al.Mahidol UniversityAgricultural and Biological SciencesBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.1371/journal.pgen.1000856