Mechanism-Based Design, Synthesis, and in Vitro Antimalarial Testing of New 4-Methylated Trioxanes Structurally Related to Artemisinin: The Importance of a Carbon-Centered Radical for Antimalarial Activity

Gary H. PosnerChang Ho OhDasong WangLucia GerenaWilbur K. MilhousSteven R. MeshnickWanida AsawamahasadkaJohns Hopkins UniversityWalter Reed Army Institute of ResearchUniversity of Michigan School of Public HealthMahidol University2018-02-272018-02-271994-04-01Journal of Medicinal Chemistry. Vol.37, No.9 (1994), 1256-125815204804002226232-s2.0-0028305219https://repository.li.mahidol.ac.th/handle/20.500.14594/9516Mahidol UniversityBiochemistry, Genetics and Molecular BiologyPharmacology, Toxicology and PharmaceuticsMechanism-Based Design, Synthesis, and in Vitro Antimalarial Testing of New 4-Methylated Trioxanes Structurally Related to Artemisinin: The Importance of a Carbon-Centered Radical for Antimalarial ActivityArticleSCOPUS10.1021/jm00035a003