White N.J.Watson J.A.Baird J.K.Mahidol University2023-06-182023-06-182022-06-01British Journal of Clinical Pharmacology Vol.88 No.6 (2022) , 2657-266403065251https://repository.li.mahidol.ac.th/handle/20.500.14594/85854Methaemoglobin results from the oxidation of ferrous to ferric iron in the centre of the haem moiety of haemoglobin. The production of dose-dependent methaemoglobinaemia by 8-aminoquinoline antimalarial drugs appears to be associated with, but is not directly linked to, therapeutic efficacy against latent Plasmodium vivax and Plasmodium ovale malarias (radical cure). Iatrogenic methaemoglobinaemia may be a useful pharmacodynamic measure in 8-aminoquinoline drug and dose optimization.MedicineReviewSCOPUS10.1111/bcp.152192-s2.0-851236875261365212534997616