Teerayut SriyatepRaymond J. AndersenBrian O. PatrickStephen G. PyneChatchai MuanprasatSawinee SeemakhanSuparerk BorwornpinyoSurat LaphookhieoMae Fah Luang UniversityThe University of British ColumbiaUniversity of WollongongMahidol University2018-12-212019-03-142018-12-212019-03-142017-05-26Journal of Natural Products. Vol.80, No.5 (2017), 1658-166715206025016338642-s2.0-85019729486https://repository.li.mahidol.ac.th/handle/20.500.14594/41925© 2017 The American Chemical Society and American Society of Pharmacognosy. Seven new caged xanthones, doitunggarcinones E-K (1-7), all as scalemic mixtures and 10 known compounds (8-17), were isolated from the stem bark extract of Garcinia propinqua. The structures were elucidated on the basis of spectroscopic methods. The separation of the enantiomers of 1-6 was achieved by semipreparative chiral HPLC. The absolute configuration of compound (+)-1 was determined by single-crystal X-ray crystallographic analysis using Cu Kα radiation. The absolute configurations of the other related compounds were determined from comparisons of their ECD spectra with that of compound (+)-1. Compounds (-)-6 and 7 showed cytotoxicity against a colon cancer cell line with IC50 values of 14.23 and 23.95 μM, respectively.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryArticleSCOPUS10.1021/acs.jnatprod.7b00240