Talerngsak KanjanabuchSongkiat LewsuwanChagriya KitiyakaraBoonyarit CheunsuchonSomchai Eiam-OngChulalongkorn UniversityMahidol University2018-08-202018-08-202006-08-01Journal of the Medical Association of Thailand. Vol.89, No.SUPPL. 2 (2006)01252208012522082-s2.0-33846029152https://repository.li.mahidol.ac.th/handle/20.500.14594/23659Focal segmental glomerulosclerosis (FSGS) is the leading cause of nephrotic syndrome in an adult worldwide. The prevalence of FSGS is estimated as being 20-30% in adults over the age of 15 years and slightly higher (30-35%) in the elderly (age > 60 years). The diagnosis solely relies on pathologic findings, which sclerosis involves some, but not all glomeruli (focal), and sclerosis affects a portion, but not the entire, glomerular tuft (segmental). The pathogenesis remains inconclusive but podocyte injury has been postulated. Even though steroid is the mainstay treatment, only 20-40% of patients are complete respond.Mahidol UniversityMedicineReviewSCOPUS