Darunee SoorukramJaray PanmuangPatoomratana TuchindaChutima KuhakarnVichai ReutrakulManat PohmakotrMahidol University2018-11-092018-11-092014-10-14Tetrahedron. Vol.70, No.41 (2014), 7577-758314645416004040202-s2.0-84907059382https://repository.li.mahidol.ac.th/handle/20.500.14594/33217© 2014 Elsevier Ltd. All rights reserved. A stereoselective approach to secolignans is described. The key synthetic strategy involves an asymmetric aldol reaction to control the creation of the stereogenic center at the β-carbon of the target secolignans. In the present work, peperomin C and its analogues, i.e., 2,6-didehydropeperomin C and 2-epi-peperomin C were successfully synthesized in good yields with high stereoselectivities.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.tet.2014.07.101