Beukeaw D.Rattanasupaponsak N.Kittikool T.Phakdeeyothin K.Phomphrai K.Yotphan S.Mahidol University2023-06-182023-06-182022-09-06Advanced Synthesis and Catalysis Vol.364 No.17 (2022) , 3066-307316154150https://repository.li.mahidol.ac.th/handle/20.500.14594/84054A substrate-controlled site-selective phosphorylation of pyrazolin-5-ones has been established under metal-free direct oxidative coupling processes. A reaction between pyrazolones and secondary phosphonates in the presence of TBAI/TBHP combination could result in the N−P bond formation at N2 position. Meanwhile, the C−P bond coupling at C3 position could be obtained from a reaction of N2-substituted pyrazolone substrates with secondary phosphine oxides using Selectfluor. These chemo- and regioselective metal-free approaches proceed in fair to high yields under mild reaction conditions with good functional group compatibility. (Figure presented.).Chemical EngineeringArticleSCOPUS10.1002/adsc.2022005332-s2.0-8513619857316154169