Tanomsri SrichaikulThitiporn SiriasawakulMahidol UniversityChulalongkorn University2018-04-192018-04-191976-01-01Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.70, No.3 (1976), 244-24618783503003592032-s2.0-0017130386https://repository.li.mahidol.ac.th/handle/20.500.14594/10874Bone marrow cultures in 15 Plasmodium falciparum patients were studied both during and after parasitaemia. Abnormalities were observed only in the group during parasitaemia. These abnormalities included: (1) decreased normoblastic number and cellular iron incorporation in all cases; (2) premature death of normoblasts during their development in the cultures in all cases; (3) defective haemoglobin synthesis in 3 of 11 cases (27%). A causal relationship between defective haemoglobin synthesis and degree of normoblastic destruction in the cultures was found. Marked anaemia and depressed C’ 3 level were found only in the group with defective haemoglobin synthesis. The significance of these findings is discussed. © 1976 Oxford University Press.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.1016/0035-9203(76)90048-1