Hataikarn NimitphongEunmi ParkMi Jeong LeeFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityCollege of Tropical Agriculture and Human ResourcesHannam University2020-12-282020-12-282020-12-01Nutrition Research and Practice. Vol.14, No.6 (2020), 553-56720056168197614572-s2.0-85097389431https://repository.li.mahidol.ac.th/handle/20.500.14594/60343© 2020 The Korean Nutrition Society and the Korean Society of Community Nutrition. Vitamin D insufficiency is associated with obesity and its related metabolic diseases. Adipose tissues store and metabolize vitamin D and expression levels of vitamin D metabolizing enzymes are known to be altered in obesity. Sequestration of vitamin D in large amount of adipose tissues and low vitamin D metabolism may contribute to the vitamin D inadequacy in obesity. Vitamin D receptor is expressed in adipose tissues and vitamin D regulates multiple aspects of adipose biology including adipogenesis as well as metabolic and endocrine function of adipose tissues that can contribute to the high risk of metabolic diseases in vitamin D insufficiency. We will review current understanding of vitamin D regulation of adipose biology focusing on vitamin D modulation of adiposity and adipose tissue functions as well as the molecular mechanisms through which vitamin D regulates adipose biology. The effects of supplementation or maintenance of vitamin D on obesity and metabolic diseases are also discussed.Mahidol UniversityAgricultural and Biological SciencesReviewSCOPUS10.4162/nrp.2020.14.6.553