Thatsaphan SrithongkulPatompong UngprasertFaculty of Medicine, Siriraj Hospital, Mahidol University2020-05-052020-05-052020-01-01European Journal of Internal Medicine. (2020)18790828095362052-s2.0-85083362934https://repository.li.mahidol.ac.th/handle/20.500.14594/54643© 2020 European Federation of Internal Medicine Background: Recent studies have suggested a renal protective effect of coffee consumption against development of chronic kidney disease (CKD) although the results remain inconclusive. This systematic review and meta-analysis aimed to comprehensively investigate this association by summarizing all available data. Methods: A systematic review was performed using MEDLINE and EMBASE database from inception to November 2019 to identify all cohort studies that compared the risk of developing CKD after index date among coffee-drinkers versus non-drinkers. Pooled risk ratio and 95% confidence interval (CI) were calculated using random-effect, generic inverse-variance method of DerSimonian and Laird. Results: A total of 4 cohort studies comprising of 25,849 participants met the inclusion criteria and were analyzed in the meta-analysis. The meta-analysis found a significantly decreased risk of incident CKD among coffee-drinkers compared with non-drinkers with the pooled risk ratio of 0.87 (95% CI, 0.81-0.95; I2 of 57%). The funnel plot of this study was relatively symmetric and was not indicative of publication bias Conclusions: A significant association between coffee consumption and a lower risk of incident CKD was demonstrated in this study.Mahidol UniversityMedicineArticleSCOPUS10.1016/j.ejim.2020.04.018