H. Rob TaalBeate St PourcainElisabeth ThieringShikta DasDennis O. Mook-KanamoriNicole M. WarringtonMarika KaakinenEskil Kreiner-MøllerJonathan P. BradfieldRachel M. FreathyFrank GellerMònica GuxensDiana L. CousminerMarjan KerkhofNicholas J. TimpsonM. Arfan IkramLawrence J. BeilinKlaus BønnelykkeJessica L. BuxtonPimphen CharoenBo Lund Krogsgaard ChawesJohan ErikssonDavid M. EvansAlbert HofmanJohn P. KempCecilia E. KimNorman KloppJari LahtiStephen J. LyeGeorge McmahonFrank D. MentchMartina Müller-NurasyidPaul F. O'reillyInga ProkopenkoFernando RivadeneiraEric A.P. SteegersJordi SunyerCarla TieslerHanieh YaghootkarMyriam FornageAlbert V. SmithSudha SeshadriReinhold SchmidtStéphanie DebetteHenri A. VroomanSigurdur SigurdssonStefan RopeleLaura H. CokerW. T. LongstrethWiro J. NiessenAnita L. DestefanoAlexa BeiserAlex P. ZijdenbosErasmus University Medical CenterUniversity of BristolHelmholtz Center Munich German Research Center for Environmental HealthImperial College LondonWeill Cornell Medicine-QatarUniversity of Western Australia Faculty of Medicine and DentistryUniversity of TorontoOulun YliopistoKobenhavns UniversitetThe Children's Hospital of PhiladelphiaUniversity of ExeterStatens Serum InstitutCentre de Recerca en Epidemiologia Ambiental, BarcelonaHospital del MarCIBER Epidemiologia Y Salud PublicaHelsingin YliopistoUniversity of Groningen, University Medical Center GroningenNetherlands Consortium for Healthy Ageing (NCHA)Mahidol UniversityNational Institute for Health and WelfareMedizinische Hochschule Hannover (MHH)Ludwig-Maximilians-Universitat MunchenKlinikum der Universitat MunchenUniversity of OxfordWellcome Trust Centre for Human GeneticsUniversitat Pompeu FabraGerman Center for Neurodgenerative Diseases (DZNE)Boston University School of MedicineBoston University School of Public HealthInsermUniversity of Texas School of Public HealthIcelandic Research InstituteUniversity of IcelandNational Institute on AgingUniversity of Mississippi Medical CenterFramingham Heart StudyEuropean Bioinformatics InstituteUniversity of PennsylvaniaCenter for Public Health Research (CSISP)Centre National de GenotypageFondation Jean Dausset - CEPHOntario Institute for Cancer ResearchBroad InstituteWellcome Trust Sanger InstituteLondon School of Hygiene & Tropical MedicineUniversity of California, DavisChurchill HospitalCentro de Regulacion GenomicaHealth Protection AgencyThe University of North Carolina at Chapel HillIta-Suomen yliopistoVrije Universiteit AmsterdamUCLKing's College LondonNational University of SingaporeUniversitat Duisburg-EssenChildren's Hospital BostonHarvard Medical SchoolUniversity of SouthamptonInstitut for SygdomsforebyggelseUniversity of Copenhagen, Faculty of Health SciencesUniversity of EdinburghUniversity Hospital of TampereTampereen YliopistoUniversity of TartuChildren's Hospital of IowaHarokopio UniversityMid Sweden University, OstersundTurun yliopistoSt George's University of LondonHarvard Pilgrim Health Care InstituteUniversitat PotsdamCharité – Universitätsmedizin BerlinMRC Epidemiology UnitUniversity of DundeeSingapore Eye Research InstituteMedizinische Universitat GrazWake Forest University School of MedicineUniversity of Washington, SeattleDelft University of TechnologyUniversite de MontrealMayo ClinicLeiden University Medical Center - LUMC2018-06-112018-06-112012-05-01Nature Genetics. Vol.44, No.5 (2012), 532-53815461718106140362-s2.0-84860324077https://repository.li.mahidol.ac.th/handle/123456789/13752To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10 -9 ) and rs1042725 on chromosome 12q15 (P = 2.8 × 10 -10 ) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height, their effects on infant head circumference were largely independent of height (P = 3.8 × 10 -7 for rs7980687 and P = 1.3 × 10 -7 for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 × 10 -6 ). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life. © 2012 Nature America, Inc. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1038/ng.2238