Karn WijarnpreechaWasin AhujaSupavit ChesdachaiCharat ThongprayoonVeeravich JaruvongvanichWisit CheungpasitpornPatompong UngprasertFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityUniversity of Hawaii at ManoaFaculty of Medicine, Siriraj Hospital, Mahidol UniversityMayo ClinicYale UniversityBassett Medical Center2019-08-282019-08-282018-01-01Diseases of the Colon and Rectum. Vol.61, No.4 (2018), 476-48315300358001237062-s2.0-85046563057https://repository.li.mahidol.ac.th/handle/20.500.14594/47230© The ASCRS 2018. BACKGROUND: The possible relationship between obesity and the risk of colonic diverticulosis has been suggested by recent epidemiologic studies, although the results were inconsistent. OBJECTIVE: This systematic review and meta-Analysis was conducted to summarize all of the available data. DATA SOURCES: A comprehensive literature review was conducted using the MEDLINE and EMBASE databases through January 2017. STUDY SELECTION: Studies that compared the risk of colonic diverticulosis among subjects with obesity versus those without obesity were included. MAIN OUTCOME MEASURES: Effect estimates from each study were extracted and combined together using a random-effect, generic inverse variance method. RESULTS: Of 2989 potentially eligible articles, 10 studies (9 cross-sectional studies and 1 prospective cohort study) with 53,520 participants met the eligibility criteria and were included in the meta-Analysis. The risk of colonic diverticulosis in obese subjects was significantly higher than in those without obesity, with a pooled OR of 1.41 (95% CI, 1.20-1.65). The statistical heterogeneity was high, with an I2 of 75%. LIMITATIONS: High statistical heterogeneity and publication bias in favor of positive studies may have been present in this meta-Analysis. CONCLUSIONS: A significant association between colonic diverticulosis and obesity was shown in this study. However, additional studies are still required to determine the causality. See Video Abstract at http://links.lww.com/DCR/A500.Mahidol UniversityMedicineArticleSCOPUS10.1097/DCR.0000000000000999