Isaraporn PolbupphaWisanu ManeeratTawanun SripisutThunwadee LimtharakulSarot CheenprachaStephen G. PyneChatchai MuanprasatSawinee SeemakhanSuparerk BorwornpinyoSurat LaphookhieoMae Fah Luang UniversityChiang Mai UniversityUniversity of PhayaoUniversity of WollongongMahidol University2018-12-212019-03-142018-12-212019-03-142017-01-01Natural Product Communications. Vol.12, No.7 (2017), 1073-1076155594751934578X2-s2.0-85026481448https://repository.li.mahidol.ac.th/handle/20.500.14594/41608The first phytochemical investigation of the twig extracts of Maclura fruticosa led to the isolation and identification of a new xanthone, maclurafruticosone (1), together with 14 known compounds (2-15). All compounds were elucidated using spectroscopic methods as well as through comparisons made with data reported in the literature. Some isolated compounds were evaluated for their antioxidant, α-glucosidase inhibitory and cytotoxic activities. Compound 4, 6 and 7 showed significant antioxidant activity against DPPH radicals with IC50values ranging from 7.45-V16.12 μM. Compound 4 also exhibited potent activity against ABTS.,h+scavenging activity with an IC50value of 0.55 iÓ 0.01 £gM which was better than positive control (ascorbic acid, IC502.35-0.17 μM). Compound 12 showed significant α-glucosidase inhibitory activity with an IC50value of 0.02-0.37 mM. Compounds 5, 6 and 12 showed weak cytotoxic activities against a colon cancer cell line with IC50values ranging from 22.35-47.62 μM.Mahidol UniversityAgricultural and Biological SciencesArticleSCOPUS