Anna KreilChristoph WenischGary BrittenhamSornchai LooareesuwanMarkus Peck-RadosavljevicUniversitat WienKarl-Franzens-Universitat GrazMahidol University2018-09-072018-09-072000-01-01British Journal of Haematology. Vol.109, No.3 (2000), 534-536000710482-s2.0-0034044675https://repository.li.mahidol.ac.th/handle/20.500.14594/26336Thrombopoietin (TPO) is the key growth factor for platelet production and is elevated in states of platelet depletion. As thrombocytopenia is a common finding in malaria, we analysed TPO regulation before, during and after antimalarial treatment. Before treatment, TPO serum levels were significantly higher in patients with severe malaria (n = 35) than in patients with uncomplicated malaria (n = 44; P = 0.024), normalizing within 14-21 d of therapy. The rapid normalization of TPO levels and increase in low peripheral platelet counts after treatment indicate that the biosynthesis of TPO and its regulation in malaria patients are normal.Mahidol UniversityMedicineArticleSCOPUS10.1046/j.1365-2141.2000.02096.x