Chiea Chuen KhorTran Nguyen Bich ChauJunxiong PangSonia DavilaHoang Truong LongRick T.H. OngSarah J. DunstanBridget WillsJeremy FarrarTa Van TramTran Thi GanNguyen Thi Nguyet BinhLe Trung TriLe Bich LienNguyen Minh TuanNguyen Thi Hong ThamMai Ngoc LanhNguyen Minh NguyetNguyen Trong HieuNguyen Van N Vinh ChauTran Thi ThuyDennis E.K. TanAnavaj SakuntabhaiYik Ying TeoMartin L. HibberdCameron P. SimmonsGenome Institute of SingaporeNational University of SingaporeYong Loo Lin School of MedicineOxford University Clinical Research UnitNuffield Department of Clinical MedicineTien Giang HospitalSa Dec HospitalChildren's Hospital No. 1Dong Thap HospitalHung Vuong HospitalUCLChildren's Hospital No. 2Institut Pasteur, ParisMahidol University2018-05-032018-05-032011-11-01Nature Genetics. Vol.43, No.11 (2011), 1139-114115461718106140362-s2.0-80055010567https://repository.li.mahidol.ac.th/handle/20.500.14594/11449Hypovolemic shock (dengue shock syndrome (DSS)) is the most common life-threatening complication of dengue. We conducted a genome-wide association study of 2,008 pediatric cases treated for DSS and 2,018 controls from Vietnam. Replication of the most significantly associated markers was carried out in an independent Vietnamese sample of 1,737 cases and 2,934 controls. SNPs at two loci showed genome-wide significant association with DSS. We identified a susceptibility locus at MICB (major histocompatibility complex (MHC) class I polypeptide-related sequence B), which was within the broad MHC region on chromosome 6 but outside the class I and class II HLA loci (rs3132468, P meta = 4.41 × 10 -11 , per-allele odds ratio (OR) = 1.34 (95% confidence interval: 1.23-1.46)). We identified associated variants within PLCE1 (phospholipase C, epsilon 1) on chromosome 10 (rs3765524, P meta = 3.08 × 10 -10 , per-allele OR = 0.80 (95% confidence interval: 0.75-0.86)). We identify two loci associated with susceptibility to DSS in people with dengue, suggesting possible mechanisms for this severe complication of dengue. © 2011 Nature America, Inc. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1038/ng.960