Thanaporn RungruangThidarut BoonmarsMahidol UniversityKhon Kaen University2018-09-132018-09-132009-09-01Southeast Asian Journal of Tropical Medicine and Public Health. Vol.40, No.5 (2009), 898-900012515622-s2.0-70349823679https://repository.li.mahidol.ac.th/handle/123456789/27948We investigated the in vivo antimalarial effect of crude extract of Tinospora crispa, a Thai traditional medicine plant. Mice were inoculated with Plasmodium yoelii then treated with the crude extract of Tinospora crispa at doses of 20, 40 and 80 mg/kg. Mice receiving the dose of 20 mg/kg died on average on Day 8. Mice remained alive longer when treated of the dose of 40 mg/kg or even longer under the treatment of the dose of 80 mg/kg. Surprisingly and interestingly, one mouse from the group in which the dose of 80 mg/kg was administrated is still alive and the parasite was cleared from the blood stream. In conclusion, T. crispa has an in vivo antimalarial effect in dose dependent manner.Mahidol UniversityMedicineArticleSCOPUS