Megan E. CareyWilliam R. MacWrightJustin ImJames E. MeiringMalick M. GibaniSe Eun ParkAshley LongleyHyon Jin JeonCaitlin HemlockAlexander T. YuAbdramane SouraKristen AiemjoyEllis Owusu-DaboMekonnen TerferiSahidul IslamOctavie LunguyaJan JacobsMelita GordonChristiane DolecekStephen BakerVirginia E. PitzerMohammad Tahir YousafzaiSusan TonksJohn D. ClemensKashmira DateFirdausi QadriRobert S. HeydermanSamir K. SahaBuddha BasnyatIruka N. OkekeFarah N. QamarMerryn VoyseyStephen LubyGagandeep KangJason AndrewsAndrew J. PollardJacob JohnDenise GarrettFlorian MarksOxford University Clinical Research UnitMalawi-Liverpool-Wellcome Trust Clinical Research ProgrammeUniversity of OuagadougouKwame Nkrumah University of Science and TechnologyArmauer Hansen Research InstituteInternational Vaccine Institute, SeoulThe Aga Khan UniversityUniversity of CambridgeUCLA Fielding School of Public HealthPrins Leopold Instituut voor Tropische GeneeskundeDhaka Shishu HospitalUniversity of OxfordKU LeuvenUniversity of California, BerkeleyUniversity College LondonCenters for Disease Control and PreventionUniversity of LiverpoolImperial College LondonMahidol UniversityStanford UniversityInternational Centre for Diarrhoeal Disease Research BangladeshNuffield Department of MedicineUniversity of IbadanYale UniversityChristian Medical College, VellorePublic Health Surveillance GroupThe Albert B. Sabin Vaccine Institute, Inc.Institut National de Recherche Biomédicale2020-08-252020-08-252020-07-29Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. Vol.71, No.2 (2020), S102-S110153765912-s2.0-85088880600https://repository.li.mahidol.ac.th/handle/123456789/58058© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. Building on previous multicountry surveillance studies of typhoid and others salmonelloses such as the Diseases of the Most Impoverished program and the Typhoid Surveillance in Africa Project, several ongoing blood culture surveillance studies are generating important data about incidence, severity, transmission, and clinical features of invasive Salmonella infections in sub-Saharan Africa and South Asia. These studies are also characterizing drug resistance patterns in their respective study sites. Each study answers a different set of research questions and employs slightly different methodologies, and the geographies under surveillance differ in size, population density, physician practices, access to healthcare facilities, and access to microbiologically safe water and improved sanitation. These differences in part reflect the heterogeneity of the epidemiology of invasive salmonellosis globally, and thus enable generation of data that are useful to policymakers in decision-making for the introduction of typhoid conjugate vaccines (TCVs). Moreover, each study is evaluating the large-scale deployment of TCVs, and may ultimately be used to assess post-introduction vaccine impact. The data generated by these studies will also be used to refine global disease burden estimates. It is important to ensure that lessons learned from these studies not only inform vaccination policy, but also are incorporated into sustainable, low-cost, integrated vaccine-preventable disease surveillance systems.Mahidol UniversityMedicineArticleSCOPUS10.1093/cid/ciaa367