Teerachai PunirunDarunee SoorukramChutima KuhakarnVichai ReutrakulManat PohmakotrMahidol University2019-08-232019-08-232018-01-19Journal of Organic Chemistry. Vol.83, No.2 (2018), 765-78215206904002232632-s2.0-85040832855https://repository.li.mahidol.ac.th/handle/20.500.14594/45512© 2017 American Chemical Society. An efficient C1-difluoromethylation of tetrahydroisoquinolenes was achieved using TMSCF2SPh as a difluoromethylating agent and 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate (TEMPO+BF4-) as an oxidant. The process provides an access to a variety of C1-difluoro(phenylsulfanyl)methylated tetrahydroisoquinoline adducts in good yields. These adducts were employed as key precursors for preparing fluorinated pyrrolo[2,1-a]isoquinoline and benzo[a]quinolizidines.Mahidol UniversityChemistryArticleSCOPUS10.1021/acs.joc.7b02783