Pimlak CharoenkwanSupatra SirichotiyakulPharuhas ChanprapaphFuanglada TongprasertRawee TaweepholRattika Sae-TungTorpong SanguansermsriChiang Mai UniversityMahidol University2018-08-202018-08-202006-12-01Journal of Pediatric Hematology/Oncology. Vol.28, No.12 (2006), 827-83015363678107741142-s2.0-33845686816https://repository.li.mahidol.ac.th/handle/20.500.14594/23445Hemoglobin Constant Spring (Hb CS) is an unstable hemoglobin (Hb) variant that results from a nucleotide substitution at the termination codon of the α2-globin gene. The compound heterozygosity of α-thalassemia and Hb CS (-/αα) results in a Hb H/CS disease which is clinically more severe than deletional Hb H disease. Homozygosity of Hb CS (αα/ αα) is generally characterized with mild hemolytic anemia, jaundice, and splenomegaly. The authors report 1 case with Hb CS homozygosity who presented with fetal anemia and hydrops. Intrauterine transfusions were given which rendered a favorable outcome. This report demonstrates an unusual and serious in utero complication in a fetus with Hb CS/CS. © 2006 Lippincott Williams & Wilkins, Inc.Mahidol UniversityMedicineArticleSCOPUS10.1097/01.mph.0000243662.56432.37