Suwanpitak S.Chanprasert C.Netsrithong R.Plengvidhya N.Yenchitsommanus P.t.Wattanapanitch M.Thamtarana P.J.Mahidol University2023-06-182023-06-182022-08-01Stem Cell Research Vol.63 (2022)18735061https://repository.li.mahidol.ac.th/handle/20.500.14594/83658Two heterozygous mutations (p.L475P in ZYG11A and p.E51K in GATA6) were identified in a family with autosomal dominant diabetes. ZYG11A-p.L475P was proposed as a causative mutation because of the complete segregation with hyperglycemia and the proven pathogenic effect on beta-cell expansion. The modifying effect of GATA6-p.E51K was proposed owing to the earlier onset of the carriers. Herein, we establish a line of induced pluripotent stem cells (iPSCs) from peripheral blood mononuclear cells (PBMCs) of a proband who carries both mutations using Sendai viral vectors. The generated iPSC line was characterized for pluripotency, chromosomal normality, and authentication.Biochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1016/j.scr.2022.1028712-s2.0-851344724871876775335853413