Tanatsaparn TithitoPanan SuntornsaratoonNarattaphol CharoenphandhuJirawan ThongbunchooNateetip KrishnamraI. Ming TangWeeraphat Pon-OnKasetsart UniversityMahidol UniversityKing Mongkut s University of Technology ThonburiAcademy of Science2020-01-272020-01-272019-03-01Biomedical Materials (Bristol). Vol.14, No.2 (2019)1748605X174860412-s2.0-85062109085https://repository.li.mahidol.ac.th/handle/20.500.14594/50520© 2019 IOP Publishing Ltd. In the present study, composite scaffolds of chitosan-graft-poly(methyl methacrylate) (Chi-g-PMMA) and mineral ions-loaded hydroxyapatite (mHA) (obtained by the hydrothermal treatment of hydroxyapatite (HA) in a simulated body fluid (SBF) solution (mHA@Chi-g-PMMA)) were prepared by the blending method. The physical properties, bioactivity, biological properties and their capabilities for sustained drug and protein release were studied. Physicochemical analysis showed a successful incorporation of the mineral ions in the HA particles and a good distribution of the mHA within the Chi-g-PMMA polymer matrix. The compressive strength and the Young's modulus were 15.760 ± 0.718 and 658.452 ± 17.020 MPa, respectively. In bioactivity studies, more apatite formation on the surface were seen after immersion in the SBF solution. In vitro growth experiments using UMR-106 osteoblast-like cells on the mHA@Chi-g-PMMA scaffold case showed that the attachment, viability and proliferation of the cells on the scaffolds had improved after 7 d of immersion. The in vitro release of two compounds (the cancer drug, doxorubicin (DOX)) and bovine serum albumin (BSA)), which had been attached to separate mHA@Chi-g-PMMA scaffolds, were studied to determine their suitability as drug delivery vehicles. It was found that the sustained release of DOX was 73.95% and of BSA was 57.27% after 25 h of incubation. These experimental results demonstrated that the mHA@Chi-g-PMMA composite can be utilized as a scaffold for bone cells ingrowth and also be used for drug delivery during the bone repairing.Mahidol UniversityChemical EngineeringEngineeringMaterials ScienceArticleSCOPUS10.1088/1748-605X/ab025f