Apirak PuntumchaiPrasat KittakoopShuleewan RajviroongitSaovaluk VimuttipongKittisak LikhitwitayawuidYodhathai ThebtaranonthMahidol UniversityThailand National Center for Genetic Engineering and BiotechnologyChulalongkorn University2018-07-242018-07-242004-03-01Journal of Natural Products. Vol.67, No.3 (2004), 485-486016338642-s2.0-1642506128https://repository.li.mahidol.ac.th/handle/20.500.14594/21222Two new stilbene derivatives, lakoochins A (1) and B (2), were isolated from the roots of Artocarpus lakoocha. The structures of 1 and 2 were elucidated by analysis of their spectral data. Lakoochins A (1) and B (2) exhibited antimycobacterial activity with the respective MIC values of 12.5 and 50 μg/mL. While 1 was cytotoxic against the BC (breast cancer) cell line (IC50 6.1 μg/mL) but inactive (at 20 μg/mL) toward KB (nasopharyngeal carcinoma) cells, compound 2 possessed cytotoxicity against the BC and KB cell lines with IC50 values of 3.1 and 6.1 μg/mL, respectively.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1021/np030429e