Chantcharas P.Mahidol University2025-02-052025-02-052025-01-01Journal of Population and Social Studies Vol.33 (2025) , 633-650https://repository.li.mahidol.ac.th/handle/20.500.14594/104170This study explores the complex experiences of children living with HIV (CLHIV) who were born to mothers living with HIV (MLHIV), particularly during their transition into adolescence and beyond, aiming to enhance their well-being. By investigating life experiences and determinants of well-being, the research seeks to uncover intricate challenges and offer insights into the factors influencing their well-being. The study uses a mixed-methods approach, combining a cross-sectional survey with structured tools and case studies involving in-depth interviews for a comprehensive analysis. The study settings encompass community and provincial hospitals in two provinces within Thailand’s Central region, chosen for the presence of organizations supporting people living with HIV (PLHIV). The study examines well-being using standardized instruments: the Pictorial Thai Self-Esteem Scale (PTSS) and the PedsQL™ 4.0: Pediatric Quality of Life Inventory TM (Thai version). The findings illuminate various challenges faced by CLHIV, such as educational barriers, psychosocial difficulties, and stigma and discrimination rooted in past experiences. Recommendations emphasize the importance of quality education and employment opportunities, alongside addressing psychosocial challenges, to support the well-being of CLHIV. The study’s outcomes provide valuable insights for policymakers, healthcare providers, and organizations working with CLHIV, guiding future interventions and policies to uplift this vulnerable population.Social SciencesArticleSCOPUS10.25133/JPSSV332025.0342-s2.0-8520974876524654418