Boonmee SathapatayavongsPaisan LeelachaikulRoongnapa PrachaktamVichai AtichartakarnSuthus SriphojanartPrasert TrairatvorakulSopon JirasirithamSuwattana NontasutCharindr EurvilaichitTimothy FlegelMahidol University2018-06-142018-06-141989-01-01Journal of Infectious Diseases. Vol.159, No.2 (1989), 274-28015376613002218992-s2.0-0024501169https://repository.li.mahidol.ac.th/handle/20.500.14594/15832Pythium infection (pythiosis) in humans has not previously been described, even in areas endemic for animal pythiosis. We report five patients with a unique presentation of fungal arteritis. The medium- to large-sized arteries were involved, and in some cases this involvement led to gangrene of the limbs, aneurysm formation, and ultimately fatal arterial leakage. All five patients were farmers. All patients, with the possible exception of one who had hemoglobin typing performed after receiving a blood transfusion, had thalassemia hemoglobinopathy syndrome. Fungal isolation was difficult. Amphotericin B treatment seemed to be ineffective. Radical surgical removal of infected tissues and oral administration of a saturated solution of potassium iodide are proposed therapy. In the tropics, where Pythium is ubiquitous, one should actively look for this fungal infection in patients with unexplained arterial occlusion, especially in the case of patients with thalassemia hemoglobinopathy syndrome. © 1989, by The University of Chicago. All Rights Reserved.Mahidol UniversityMedicineArticleSCOPUS10.1093/infdis/159.2.274