Sorawut ThamyongkitUkris GhunadhamPaphon Sa-NgasoongsongChanika AngsanuntsukhUmaporn SuthutvoravutPatarawan WoratanaratPornchai MulpruekFaculty of Medicine, Ramathibodi Hospital, Mahidol University2020-10-052020-10-052020-08-01Journal of the Medical Association of Thailand. Vol.103, No.8 (2020), 804-808012522082-s2.0-85089938615https://repository.li.mahidol.ac.th/handle/20.500.14594/59200© JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND. Objective: To find the correlation between the presence of childhood obesity and bone mineral density (BMD). Materials and Methods: A cross-sectional study was conducted among children aged between 5 and 12 years old. After excluding children who had history of endocrinopathy, epilepsy, or cerebral palsy, all participants were divided into "obese group"(body mass index [BMI] at or above the 95 percentile of those with the same age and gender) and "control group"(BMI below the 95 percentile). Skeletal age, BMD, serum bone markers (osteocalcin and beta-crosslaps), and physical exercise were collected. Multivariate regression analysis was used for statistical analysis. Results: Ninety-six obese children and 98 controls were included in the present study. The average BMI was 28.5 kg/m2 in obese group, and 16.6±1.9 kg/m2 in controls (p<0.001). BMDs of the spine and hip area were significantly higher in obese group compared to controls (p=0.002 and <0.001, respectively). However, there was no significant difference of skeletal age or serum bone markers level between both groups (p>0.05 all). Exercise was shown to significantly correlated with hip and distal radius BMD (p<0.001 and 0.003, respectively). Conclusion: Obese children had significantly higher spine and hip BMD than non-obese children. Nevertheless, there were no differences between groups regarding skeletal age and bone markers. BMI and exercise activity might play an important role in higher BMD in children.Mahidol UniversityMedicineArticleSCOPUS10.35755/jmedassocthai.2020.08.10085