Karn WijarnpreechaPanadeekarn PanjawatananWuttiporn ManatsathitWisit CheungpasitpornSurakit PungpapongFrank J. LukensPatompong UngprasertUniversity of Nebraska Medical CenterFaculty of Medicine, Siriraj Hospital, Mahidol UniversityUniversity of Mississippi Medical CenterMayo Clinic in Jacksonville, FloridaChiang Mai UniversityBassett Medical Center2019-08-232019-08-232018-12-01Journal of Gastrointestinal Surgery. Vol.22, No.12 (2018), 2167-21761091255X2-s2.0-85050221348https://repository.li.mahidol.ac.th/handle/20.500.14594/46165© 2018, The Society for Surgery of the Alimentary Tract. Background/Objectives: Studies have suggested that the presence of juxtapapillary duodenal diverticula (JDD) could be a predisposing factor for choledocholithiasis. This systematic review and meta-analysis was conducted with the aims to summarize all available evidence to better characterize the risk. Methods: A literature search was performed using MEDLINE and EMBASE database from inception to January 2018. Cross-sectional studies that reported odd ratios (OR) comparing the risk of choledocholithiasis among individuals with JDD versus individuals without JDD were included. Pooled OR and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method. Results: Of 527 retrieved articles, 11 studies met our eligibility criteria and were included in analysis. We found a significant association between the presence of JDD and choledocholithiasis with the pooled OR of 2.30 (95% CI, 1.84–2.86). The statistical heterogeneity was moderate with an I 2 of 60%. Conclusions: A significantly increased risk of choledocholithiasis among individuals with JDD was observed in this study.Mahidol UniversityMedicineArticleSCOPUS10.1007/s11605-018-3865-z