Mohamed S. AhmedSam S. KangPathmanayaki RajamahendranNuntavan BunyapraphatsaraR. O.B. WijesekeraChun Tao CheDonald P. WallerA. S. BingelAnnamarie MartinDavid C. LankinGeoffrey A. CordellDjaja D. SoejartoHarry H.S. FongCairo University Faculty of PharmacySeoul National UniversityUniversity of ColomboMahidol UniversityUnited Nations Industrial Development OrganizationUniversity of Illinois Medical Center2018-10-122018-10-121984-01-01Journal of Natural Products. Vol.47, No.2 (1984), 331-34115206025016338642-s2.0-0021240808https://repository.li.mahidol.ac.th/handle/20.500.14594/30592ethanol extract of Aristolochia indica roots decreased fertility in both rats and hamsters when administered postcoitally (days 1-10 and 1-6, respectively). Petroleum ether (A), CHCl3(B), and aqueous (C) fractions, tested similarly in rats, were inactive and/or toxic. Partition of fraction B afforded non-acidic (D) and acidic (E) fractions. Savinin (1), isolated from fraction D and not previously reported from the Aristolochiaceae, was inactive when administered postcoitally to rats. Aristolochic acid-I (2), reported previously from A. indica and isolated from fraction E, was inactive when administered postcoitally to rats and toxic when administered postcoitally to hamsters. © 1984, American Chemical Society. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1021/np50032a017