Wasu WitoonsaridsilpOrnlaksana PaeratakulBusaba PanyarachunNarong SarisutaMahidol UniversitySrinakharinwirot UniversityFaculty of Medicine, Thammasat University2018-06-112018-06-112012-06-01AAPS PharmSciTech. Vol.13, No.2 (2012), 699-706153099322-s2.0-84862904378https://repository.li.mahidol.ac.th/handle/20.500.14594/15164The lysozyme (LZ)-entrapped mannosylated liposomes were prepared in this study by the use of N-octadecyl-d-mannopyranosylamine (SAMAN), which had been synthesized in-house and confirmed by characterization with FTIR and NMR. The reactant residues of synthesized SAMAN were found to be less than 1%. The mean sizes, zeta potentials, drug entrapment efficiencies, and loading capacities of all liposomal formulations were in the ranges of 234.7 to 431.0 nm, -10.97 to -25.80 mV, 7.52 to 14.10%, and 1.44 to 2.77%, respectively. The permeability of mannosylated LZ liposomes across Caco-2 cell monolayers was significantly enhanced to about 2.5- and 7-folds over those of conventional liposomes and solution, respectively, which might be due to the role of mannose receptor or mannose-binding protein on the intestinal enterocytes. © 2012 American Association of Pharmaceutical Scientists.Mahidol UniversityPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1208/s12249-012-9788-1