Use of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatment

Geraint R. DaviesRichard BrindleSaye H. KhooLeon J. AaronsUniversity of LiverpoolPortsmouth HospitalsUniversity of ManchesterMahidol University2018-08-202018-08-202006-09-01Antimicrobial Agents and Chemotherapy. Vol.50, No.9 (2006), 3154-3156006648042-s2.0-33748685468https://repository.li.mahidol.ac.th/handle/20.500.14594/23635Nonlinear mixed-effects analysis of serial sputum colony-counting data supports the existence of two bacillary subpopulations in sputum, eliminated at different rates. It distinguishes between combination regimens, removes bias, and greatly improves precision, with significant implications for the analysis of surrogate endpoints of "sterilization" in the development of new antituberculosis regimens. Copyright © 2006, American Society for Microbiology. All Rights Reserved.Mahidol UniversityMedicinePharmacology, Toxicology and PharmaceuticsUse of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatmentArticleSCOPUS10.1128/AAC.00774-05