Wuttichai JaideeRaymond J. AndersenMiguel A.G. ChavezYan A. WangBrian O. PatrickStephen G. PyneChatchai MuanprasatSuparerk BorwornpinyoSurat LaphookhieoMae Fah Luang UniversityMahidol UniversityUniversity of WollongongThe University of British Columbia2020-01-272020-01-272019-02-22Journal of Natural Products. Vol.82, No.2 (2019), 283-29215206025016338642-s2.0-85061291220https://repository.li.mahidol.ac.th/handle/20.500.14594/50251© 2019 American Chemical Society and American Society of Pharmacognosy. Four new chalcones (1, 10, 13, and 14), a new flavanone, (9), a new amide (8), and 19 known compounds were acquired from Melodorum siamensis. The structures were established by NMR and MS data analyses. Compounds 1 (er 1.4:1) and 2 (er 1.1:1) were scalemic and were resolved to yield -1 and (+)-1 and -2 and (+)-2, respectively. The absolute configurations of these compounds were determined from experimental and calculated ECD data. The structures and configurations of -2 and (+)-8 were identified by single-crystal X-ray diffraction analysis. Compound 11 showed nuclear factor-B inhibitory effects (IC 50 = 9 μM) in a pancreatic β cell line (MIN-6 cells).Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicineArticleSCOPUS10.1021/acs.jnatprod.8b00696