Channarong MuangnoiPimjai ChingsuwanrotePhawachaya PraengamthanachotiSaovaros SvastiSiriporn TuntipopipatMahidol University2018-06-112018-06-112012-04-01Inflammation. Vol.35, No.2 (2012), 445-45515732576036039972-s2.0-84863775468https://repository.li.mahidol.ac.th/handle/20.500.14594/14335Pro-inflammatory mediators produced during inflammatory response have been demonstrated to initiate and aggravate pathological development of several chronic diseases. Plant bioactive constituents have been reported to exert anti-inflammatory activities. Various parts of Moringa oleifera have long been used as habitual diets and traditional remedy along the tropical region. Anti-inflammatory activity of boiled M. oleifera pod extract was assessed by measuring pro-inflammatory mediator expression in the lipopolysaccharide- inducedmurine RAW264.7 macrophage cells. Prior treatment with 31-250 μg/mLM. oleifera extract for 1 h inhibited elevation of mRNA and protein level of interleukine-6, tumor necrosis factor-alpha, inducible nitric oxide synthase, and cyclooxygenease-2, induced by lipopolysaccharide for 24 h in a dose-dependent manner. The suppressive effect was mediated partly by inhibiting phosphorylation of inhibitor kappa B protein and mitogen-activated protein kinases. These results indicate that the anti-inflammatory activity from bioactive compounds present in the M. oleifera pod constituents may contribute to ameliorate the pathogenesis of inflammatory-associated chronic diseases. © 2011 Springer Science+Business Media, LLC.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.1007/s10753-011-9334-4