Mihajlo JakovljevicKlazien Matter-WalstraTakuma SugaharaTarang SharmaVladimir ReshetnikovJoav MerrickTetsuji YamadaSitaporn YoungkongJoan RoviraUniversity of KragujevacHosei UniversitySwiss Federal Office of Public HealthMahidol UniversitySechenov First Moscow State Medical UniversityUniversitat de BarcelonaHadassah University Medical CentreEvidence to Policy®Rutgers University2020-05-052020-05-052020-04-02Cost Effectiveness and Resource Allocation. Vol.18, No.1 (2020)147875472-s2.0-85082758828https://repository.li.mahidol.ac.th/handle/20.500.14594/54607© 2020 The Author(s). Since its inception in 2003, Cost Effectiveness and Resource Allocation journal has come a long way over the past 18 years. Possibly much longer than many of its contemporaries in the blossoming science of health economics might have anticipated. Today, entering 2020 it celebrates the Age of Maturity. We believe that in the third decade of XXI century the interdisciplinary science of health economics, will rejuvenate and come back to us younger than ever from its early historical roots almost a century ago. The spreading of economic globalization in several distinctive ways, either led by multinational business corporations or newly emerged Asian leadership, or both, is likely to make challenges for contemporary health systems far more serious. The fourth industrial revolution (cyber physical systems and artificial intelligence technology) and accelerated innovation in the field of E-Health and digital health, will probably change the workflow in medical and health care, and inevitably transform the labour market in the upcoming decades. So, let us be up to the task. Let us provide academic centres, industry-sponsored pharmaceutical and medical device innovation hubs, and governing authorities alike, with a powerful forum for debate on cost-effective resource allocation in the years to come.Mahidol UniversityMedicineReviewSCOPUS10.1186/s12962-020-00210-2