Surasak PrachyaSuthep WiyakruttaNongluksna SriubolmasNattaya NgamrojanavanichChulabhorn MahidolSomsak RuchirawatPrasat KittakoopChulabhorn Research InstituteChulalongkorn UniversityMahidol UniversityThe Institute of Science and Technology for Research and Development, Mahidol University2018-08-242018-08-242007-10-01Planta Medica. Vol.73, No.13 (2007), 1418-1420003209432-s2.0-36048955511https://repository.li.mahidol.ac.th/handle/20.500.14594/23975Mycoepoxydiene (1) and derivatives, deacetylmycoepoxydiene (2) and 2,3-dihydromycoepoxydiene (3), were isolated from a broth extract of the endophytic fungus, Phomopsis sp., which was isolated from a Thai medicinal plant, Hydnocarpus anthelminthicus. Compounds 1 and 2 exhibited potent cytotoxic activity, while a dihydro derivative 3 was inactive. The present work suggests that the α,β-unsaturated lactone moiety in mycoepoxydienes might be responsible for the cytotoxicity. © Georg Thieme Verlag KG Stuttgart.Mahidol UniversityAgricultural and Biological SciencesChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1055/s-2007-990240