Thanomkitti K.Pruksaeakanan C.Subchookul C.Charoenpipatsin N.Triwongwaranat D.Varothai S.Thuangtong R.Chumnumrat T.Mahidol University2023-12-162023-12-162023-01-01Siriraj Medical Journal Vol.75 No.12 (2023) , 887-893https://repository.li.mahidol.ac.th/handle/20.500.14594/91513Objective: To determine the efficacy and safety of 5% azelaic acid solution in comparison with 2% minoxidil solution in the treatment of FPHL. Materials and Methods: Twenty-six FPHL patients with Ludwig grade I or II were randomly treated with 5% azelaic acid solution or 2% minoxidil solution twice daily for 6 months. At baseline, 2, 4, and 6 months, hair density and hair shaft diameter were assessed at the targeted fixed area. At 6 months, patient and investigator assessments of hair growth were performed using a 7-point scale. Results: Hair density and hair shaft diameter in the patients treated with 5% azelaic acid and 2% minoxidil solution were significantly increased compared to the baseline in all cases and visits (P < 0.05). There were no statistically significant differences in hair density and hair shaft diameter changes between both groups (P?> 0.05). Both the investigator and patient assessments were comparable between both groups at 6 months. Pruritus was the major adverse effect reported in both groups, but only mild and all could be tolerated. Conclusion: 5% Azelaic acid solution might be an effective treatment for FPHL, comparable with 2% minoxidil, and could be an alternative treatment for FPHL in minoxidil-allergic patients and pregnant women.MedicineArticleSCOPUS10.33192/smj.v75i12.2660012-s2.0-8517906646522288082