Mahmoud Reza AzarpazhoohJennifer L. MandziaAmanda G. ThriftLuciano A. SposatoNegar MorovatdarAmin AmiriMoira K. KapralNawaf YassiCecilia BahitSubhash KaulSuvarna AlladiYongchai NilanontMariano CoppolaAntonia NuceraBrian SilverDavid WerringRobert SimisterRichard H. SwartzMayowa O. OwolabiBruce OvbiageleVladimir HachinskiAzienda Ospedaliera Sant'AndreaLondon Health Sciences CentreUniversity of MelbourneUniversity of California, San FranciscoUCLUCL Institute of NeurologyMonash UniversityUniversity of TorontoNational Institute of Mental Health and Neuro SciencesFaculty of Medicine, Siriraj Hospital, Mahidol UniversityWestern UniversityUniversity of IbadanNizam's Institute of Medical SciencesGhaem HospitalMashhad University of Medical SciencesUniversity of Massachusetts Medical SchoolCardiology DepartmentHospital Ramón Santamarina2020-01-272020-01-272019-04-15Journal of the Neurological Sciences. Vol.399, (2019), 209-213187858830022510X2-s2.0-85062388629https://repository.li.mahidol.ac.th/handle/20.500.14594/51723© 2019 Rationale: Stroke etiology and risk factors vary by age, sex, setting (hospital or community-based) and by region. Identifying these differences would improve our understanding of stroke etiology, diagnosis, and treatment. Aim: The Age, Sex and Setting in the Etiology of Stroke Study (ASSESS) is a multicenter cohort study to assess differences in stroke etiology. Methods and design: Data from all centers will be categorized according to age, sex, setting, stroke subtypes. Centers with extensive hospital- or community-based data regarding stroke from Argentina, Australia, Canada, India, Iran, Italy, Ghana, Nigeria, Thailand, the United Kingdom and the United States have agreed to participate so far. Study outcomes: The primary outcome includes differences in stroke etiology in study centers. The secondary outcomes include stroke incidence, risk factors, preventive strategies, and short- and long-term outcomes. Conclusion: ASSESS will enable comparisons of data from different regions to determine the age and sex distribution of the most common causes of stroke in each setting. This will help clinicians to tailor the assessment and treatment of stroke patients on the basis of their specific local characteristics. It will also empower stroke epidemiologists to design preventive measures by targeting the specific characteristics of each population.Mahidol UniversityMedicineArticleSCOPUS10.1016/j.jns.2019.02.024