Nateetip KrishnamraLiangchai LimlomwongsePoonratana SoogaroonMahidol University2018-10-122018-10-121983-01-01Endocrinologia Japonica. Vol.30, No.6 (1983), 707-713001372192-s2.0-0021044795https://repository.li.mahidol.ac.th/handle/20.500.14594/30471The plasma calcium concentration, urinary calcium excretion, total bone calcium content and the rate of calcium uptake and release by tibias were measured in 6 groups of rats which were kept under various treatment protocols for 8 wk. Ovariectomy led to significant hypocalcemia and a decrease in bone calcium content; the former being reversed towards normal by estrogen treatment. Chronic ethanol ingestion reduced the bone calcium content without apparent effect on plasma calcium in intact rat and further reduced (p<0.05) the bone calcium content in ovariectomized rats. The calcium uptake by the bone measured by 45Ca injected ip at zero hour was the same among the 6 groups. When 45Ca was injected ip 17 hours earlier, the disappearance of plasma 45Ca was found to be slower in ovariectomized and alcohol treated groups, indicating a higher rate of calcium movement from bone to plasma. Moreover, there was also an increase in the rate of calcium release by tibias after ovariectomy and chronic alcohol ingestion; the release was slightly greater in the condition of ovariectomy plus alcohol. The present investigation thus, provides evidence that ethanol is likely to have a direct stimulatory effect on bone resorption as well as an indirect effect through disrupting ovarian function during chronic administration. © 1983, The Japan Endocrine Society. All rights reserved.Mahidol UniversityEngineeringArticleSCOPUS10.1507/endocrj1954.30.707