Synthesis of N-substituted 4-methylene-3,4-dihydro-1(2H)-isoquinolin-1-ones via a palladium-catalysed three-component process

Ronald GriggTossapol KhamnaenShuleewan RajviroongitVisuvanathar SridharanUniversity of LeedsMahidol University2018-07-242018-07-242002-04-01Tetrahedron Letters. Vol.43, No.14 (2002), 2601-2603004040392-s2.0-0036532427https://repository.li.mahidol.ac.th/handle/20.500.14594/20072A novel palladium-catalysed three-component cascade process involving 2-iodobenzoyl chloride or methyl 2-iodobenzoate, allene and primary aliphatic or aromatic amines furnishes N-substituted 4-methylene-3,4-dihydro-1(2H)-isoquinolin-1-ones in good yield. © 2002 Elsevier Science Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsSynthesis of N-substituted 4-methylene-3,4-dihydro-1(2H)-isoquinolin-1-ones via a palladium-catalysed three-component processArticleSCOPUS10.1016/S0040-4039(02)00329-5